The Complex Association of FcγRIIb With Autoimmune Susceptibility

FcγRIIb is the only inhibitory Fc receptor and controls many aspects of immune and inflammatory responses. The observation 19 years ago that FcγRIIb−/− mice generated by gene targeting in 129 derived ES cells developed severe lupus like disease when backcrossed more than 7 generations into C57BL/6 b...

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Bibliographic Details
Main Authors: J. Sjef Verbeek, Sachiko Hirose, Hiroyuki Nishimura
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
SLE
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02061/full