A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model

A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model

Oncolytic virotherapy is a treatment approach with increasing clinical relevance, as indicated by the marked survival benefit seen in animal models and its current exploration in human patients with cancer. The use of an adenovirus vector for this therapeutic modality is common, has significant clin...

Full description

Bibliographic Details
Main Authors: Julius W. Kim, Jason Miska, Jacob S. Young, Aida Rashidi, J. Robert Kane, Wojciech K. Panek, Deepak Kanojia, Yu Han, Irina V. Balyasnikova, Maciej S. Lesniak
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virotherapy
replication-competent and replication-incompetent adenovirus
immune-competent and immune-deficient murine glioma model
tumor-specific cytotoxic T and dendritic cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770517300207

Internet

http://www.sciencedirect.com/science/article/pii/S2372770517300207

Similar Items