Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes

Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes

Abstract Background Endoplasmic reticulum (ER) stress has proinflammatory properties, and transgenic animal studies of rheumatoid arthritis (RA) indicate its relevance in the process of joint destruction. Because currently available studies are focused primarily on myeloid cells, we assessed how ER...

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Bibliographic Details
Main Authors: Pawel A. Kabala, Chiara Angiolilli, Nataliya Yeremenko, Aleksander M. Grabiec, Barbara Giovannone, Desiree Pots, Timothy R. Radstake, Dominique Baeten, Kris A. Reedquist
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Arthritis Research & Therapy
Subjects:
ER stress
Rheumatoid arthritis
Fibroblast-like synoviocytes
Dermal fibroblasts
Macrophages
RNA stability
Online Access:http://link.springer.com/article/10.1186/s13075-017-1386-x

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http://link.springer.com/article/10.1186/s13075-017-1386-x

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