Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus <i>Penicillium dipodomyis</i> YJ-11

Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus <i>Penicillium dipodomyis</i> YJ-11

Overexpression of the global regulator LaeA in a marine-derived fungal strain of <i>Penicillium dipodomyis</i> YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new...

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Bibliographic Details
Main Authors: Jing Yu, Huan Han, Xianyan Zhang, Chuanteng Ma, Chunxiao Sun, Qian Che, Qianqun Gu, Tianjiao Zhu, Guojian Zhang, Dehai Li
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Marine Drugs
Subjects:
genome mining
global regulator
LaeA
overexpression
<i>Penicillium dipodomyis</i>
sorbicillinoids
Online Access:https://www.mdpi.com/1660-3397/17/8/446

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https://www.mdpi.com/1660-3397/17/8/446

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