Point Mutation of a Non-Elastase-Binding Site in Human α1-Antitrypsin Alters Its Anti-Inflammatory Properties

Point Mutation of a Non-Elastase-Binding Site in Human α1-Antitrypsin Alters Its Anti-Inflammatory Properties

IntroductionHuman α1-antitrypsin (hAAT) is a 394-amino acid long anti-inflammatory, neutrophil elastase inhibitor, which binds elastase via a sequence-specific molecular protrusion (reactive center loop, RCL; positions 357–366). hAAT formulations that lack protease inhibition were shown to maintain...

Full description

Bibliographic Details
Main Authors: Yotam Lior, Mariana Zaretsky, David E. Ochayon, Diana Lotysh, Boris M. Baranovski, Ronen Schuster, Ofer Guttman, Amir Aharoni, Eli C. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
α1-antitryspin
protein structure
reactive center loop
recombinant protein
pharmacokinetics
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00759/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00759/full

Similar Items