A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA.

A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA.

Increased expression of IL-33 and its receptor ST2, encoded by the IL1RL1 gene, has been detected in the inflamed arteries of giant cell arteritis (GCA) patients. The aim of the present study was to investigate for the first time the potential influence of the IL33 and IL1RL1 loci on GCA predisposit...

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Bibliographic Details
Main Authors: Ana Márquez, Roser Solans, José Hernández-Rodríguez, Maria C Cid, Santos Castañeda, Marc Ramentol, Luis Rodriguez-Rodriguez, Javier Narváez, Ricardo Blanco, Norberto Ortego-Centeno, Spanish GCA Consortium, Oyvind Palm, Andreas P Diamantopoulos, Niko Braun, Frank Moosig, Torsten Witte, Lorenzo Beretta, Claudio Lunardi, Marco A Cimmino, Augusto Vaglio, Carlo Salvarani, Miguel A González-Gay, Javier Martín
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4237421?pdf=render

Internet

http://europepmc.org/articles/PMC4237421?pdf=render

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