Phylogenetic reconstruction of breast cancer reveals two routes of metastatic dissemination associated with distinct clinical outcome

Phylogenetic reconstruction of breast cancer reveals two routes of metastatic dissemination associated with distinct clinical outcome

Background: In breast cancer (BC), axillary lymph node (ALN) involvement is one of the strongest adverse prognostic factors. However, it is unclear whether loco-regional lymph node deposits are effectively the root of secondary metastases or only an indicator of competence of the primary tumour to s...

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Bibliographic Details
Main Authors: David Venet, Danai Fimereli, Françoise Rothé, Bram Boeckx, Marion Maetens, Samira Majjaj, Ghizlane Rouas, Maria Capra, Giuseppina Bonizzi, Federica Contaldo, Christine Galant, Martine Piccart, Giancarlo Pruneri, Denis Larsimont, Diether Lambrechts, Christine Desmedt, Christos Sotiriou
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:EBioMedicine
Subjects:
Breast cancer
Metastatic dissemination
Axillary lymph node
Distant metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420301687

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