Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens

Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens

The status quo for combating uprising antibacterial resistance is to employ synergistic combinations of antibiotics. Nevertheless, the currently available combination therapies are fast becoming untenable. Combining antibiotics with various FDA-approved non-antibiotic drugs has emerged as a novel st...

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Bibliographic Details
Main Authors: Maytham Hussein, Xiaohan Hu, Olivia K.A. Paulin, Simon Crawford, Qi Tony Zhou, Mark Baker, Elena K. Schneider-Futschik, Yan Zhu, Jian Li, Tony Velkov
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Antimicrobial resistance
Antimicrobial peptides
Phenothiazines
Metabolomics
MDR
Gram-negative
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020303615

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http://www.sciencedirect.com/science/article/pii/S2001037020303615

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