Beneficial effects of canagliflozin in combination with pioglitazone on insulin sensitivity in rodent models of obese type 2 diabetes.

Beneficial effects of canagliflozin in combination with pioglitazone on insulin sensitivity in rodent models of obese type 2 diabetes.

BACKGROUND:Despite its insulin sensitizing effects, pioglitazone may induce weight gain leading to an increased risk of development of insulin resistance. A novel sodium glucose co-transporter 2 (SGLT2) inhibitor, canagliflozin, provides not only glycemic control but also body weight reduction throu...

Full description

Bibliographic Details
Main Authors: Yoshinori Watanabe, Keiko Nakayama, Nobuhiko Taniuchi, Yasushi Horai, Chiaki Kuriyama, Kiichiro Ueta, Kenji Arakawa, Takaaki Senbonmatsu, Masaharu Shiotani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4304810?pdf=render

Internet

http://europepmc.org/articles/PMC4304810?pdf=render

Similar Items