κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats

κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats

Although opioids are potent analgesics, a consequence of chronic opioid use is hyperalgesia during withdrawal, which may contribute to opioid misuse. Dynorphin, the endogenous ligand of κ-opioid receptors (KORs), is upregulated in opioid-dependent rats and in animal models of chronic pain. However,...

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Bibliographic Details
Main Authors: Renata C.N. Marchette, Adriana Gregory-Flores, Brendan J. Tunstall, Erika R. Carlson, Shelley N. Jackson, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro F. Vendruscolo
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Neurobiology of Stress
Subjects:
Dynorphin
Negative affect
Opioid use disorder
Sex differences
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289521000333

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http://www.sciencedirect.com/science/article/pii/S2352289521000333

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