BSA-Stabilized Mesoporous Organosilica Nanoparticles Reversed Chemotherapy Resistance of Anaplastic Thyroid Cancer by Increasing Drug Uptake and Reducing Cellular Efflux

BSA-Stabilized Mesoporous Organosilica Nanoparticles Reversed Chemotherapy Resistance of Anaplastic Thyroid Cancer by Increasing Drug Uptake and Reducing Cellular Efflux

Anaplastic thyroid cancer (ATC) is a highly aggressive and the most lethal type of thyroid cancer. The standard-of-care for unresectable ATC is radiotherapy and chemotherapy, usually based on doxorubicin (Dox). However, most patients develop resistance shortly after treatment. To overcome the drug r...

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Bibliographic Details
Main Authors: Xiao Han, Xiaoquan Xu, Yuxia Tang, Feipeng Zhu, Ying Tian, Wei Liu, Doudou He, Guangming Lu, Yunfei Gu, Shouju Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
anaplastic thyroid cancer
chemotherapy resistance
bovine serum albumin
drug efflux
organosilica
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.610084/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2020.610084/full

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