Influence of Hypoxia on the Epithelial-Pathogen Interactions in the Lung: Implications for Respiratory Disease

Influence of Hypoxia on the Epithelial-Pathogen Interactions in the Lung: Implications for Respiratory Disease

Under normal physiological conditions, the lung remains an oxygen rich environment. However, prominent regions of hypoxia are a common feature of infected and inflamed tissues and many chronic inflammatory respiratory diseases are associated with mucosal and systemic hypoxia. The airway epithelium r...

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Bibliographic Details
Main Authors: Lee K. Page, Karl J. Staples, C. Mirella Spalluto, Alastair Watson, Tom M. A. Wilkinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
epithelial cells
hypoxia
hypoxia-inducible factor (HIF)-1
host-pathogen interactions
innate immunity
respiratory disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.653969/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.653969/full

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