A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood

A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood

Summary: B cell receptors (BCRs) display a combination of variable (V)-gene-encoded complementarity determining regions (CDRs) and adaptive/hypervariable CDR3 loops to engage antigens. It has long been proposed that the former tune for recognition of pathogens or groups of pathogens. To experimental...

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Bibliographic Details
Main Authors: Maya Sangesland, Ashraf S. Yousif, Larance Ronsard, Samuel W. Kazer, Alex Lee Zhu, G. James Gatter, Matthew R. Hayward, Ralston M. Barnes, Maricel Quirindongo-Crespo, Daniel Rohrer, Nils Lonberg, Douglas Kwon, Alex K. Shalek, Daniel Lingwood
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
BCR
germline
VH
pattern-recognition
bacteria
antiseptic
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720310500

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http://www.sciencedirect.com/science/article/pii/S2211124720310500

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