Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry. We discovered distinct age-related changes in bot...

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Bibliographic Details
Main Authors: Tobias Brandt, Arnaud Mourier, Luke S Tain, Linda Partridge, Nils-Göran Larsson, Werner Kühlbrandt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
ageing
mitochondrial inner membrane
membrane structure
cryo-tomography
respiratory activity
peroxide radicals
Online Access:https://elifesciences.org/articles/24662

Internet

https://elifesciences.org/articles/24662

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