XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature
Xeroderma Pigmentosum group C (XP-C) is a rare genetic disorder characterised by deficient DNA repair leading to skin and internal cancer, but the latter is not well understood molecularly. Here the authors sequence genomes of non-skin cancers from XP-C patients to unravel its mutational patterns.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19633-9 |