TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727

TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727

Pancreatic adenocarcinoma (PDAC) is one of the most deadly cancers in the Western world because of a lack of early diagnostic markers and efficient therapeutics. At the time of diagnosis, more than 80% of patients have metastasis or locally advanced cancer and are therefore not eligible for surgical...

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Bibliographic Details
Main Authors: Vincent Drubay, Nicolas Skrypek, Lucie Cordiez, Romain Vasseur, Céline Schulz, Nihad Boukrout, Belinda Duchêne, Lucie Coppin, Isabelle Van Seuningen, Nicolas Jonckheere
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Cancers
Subjects:
TGF-βRII receptor
STAT3
metastasis
gemcitabine
ABC transporters
pancreas
Online Access:http://www.mdpi.com/2072-6694/10/8/254

Internet

http://www.mdpi.com/2072-6694/10/8/254

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