Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease

Abstract Genetic variants annotated to the hedgehog interacting protein (HHIP) are robustly associated with chronic obstructive pulmonary disease (COPD). Hhip haploinsufficiency in mice leads to increased susceptibility towards the development of emphysema following exposure to chronic cigarette smo...

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Bibliographic Details
Main Authors: Emily S. Wan, Yan Li, Taotao Lao, Weiliang Qiu, Zhiqiang Jiang, John D. Mancini, Caroline A. Owen, Clary Clish, Dawn L. DeMeo, Edwin K. Silverman, Xiaobo Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02701-4