Modulation of Antibody Responses to the V1V2 and V3 Regions of HIV-1 Envelope by Immune Complex Vaccines

Modulation of Antibody Responses to the V1V2 and V3 Regions of HIV-1 Envelope by Immune Complex Vaccines

Prophylactic HIV vaccines must elicit antibodies (Abs) against the virus envelope glycoproteins (Env) to effectively prevent HIV infection. We investigated a vaccine platform that utilizes immune complexes made of Env proteins gp120 and monoclonal Abs (mAbs) against different gp120 epitopes. We prev...

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Bibliographic Details
Main Authors: Catarina E. Hioe, Rajnish Kumar, Chitra Upadhyay, Muzafar Jan, Alisa Fox, Vincenza Itri, Kristina K. Peachman, Mangala Rao, Lily Liu, Nathan C. Lo, Michael Tuen, Xunqing Jiang, Xiang-Peng Kong, Susan Zolla-Pazner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
vaccine
HIV
envelope
antibody
immune complex
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02441/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02441/full

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