2-Deoxystreptamine Conjugates by Truncation–Derivatization of Neomycin

2-Deoxystreptamine Conjugates by Truncation–Derivatization of Neomycin

A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization. The dimeric conjugates were evaluated for antibacterial activity w...

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Bibliographic Details
Main Authors: Floris L. van Delft, Floris P.J.T. Rutjes, Gerard W. Canters, Alessio Andreoni, Leandro C. Tabares, M. Waqar Aslam
Format: Article
Language:English
Published: MDPI AG 2010-03-01
Series:Pharmaceuticals
Subjects:
aminoglycosides
morpholine
aminopyridine
aminoquinoline
hemocyanin
biosensor
fluorescence
Online Access:http://www.mdpi.com/1424-8247/3/3/679/

Internet

http://www.mdpi.com/1424-8247/3/3/679/

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