Mutations in the β-amyloid precursor protein in familial Alzheimer’s disease increase Aβ oligomer production in cellular models

Mutations in the β-amyloid precursor protein in familial Alzheimer’s disease increase Aβ oligomer production in cellular models

Soluble oligomers of amyloid-β (Aβ) peptides (AβOs) contribute to neurotoxicity in Alzheimer’s disease (AD). However, it currently remains unknown whether an increase in AβOs is the common phenotype in cellular and animal models. Furthermore, it has not yet been established whether experimental stud...

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Bibliographic Details
Main Authors: Yoichi Ohshima, Katsutoshi Taguchi, Ikuko Mizuta, Masaki Tanaka, Takami Tomiyama, Fuyuki Kametani, Chihiro Yabe-Nishimura, Toshiki Mizuno, Takahiko Tokuda
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Heliyon
Subjects:
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844017332048

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http://www.sciencedirect.com/science/article/pii/S2405844017332048

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