Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

Abstract Background Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular location of NLRP3 inflammasome in cerebral I/R has yet come to a conclusion, and there is still no specific evidenc...

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Bibliographic Details
Main Authors: Zhe Gong, Jingrui Pan, Qingyu Shen, Mei Li, Ying Peng
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Stroke
NLRP3 inflammasome
Mitochondrial dysfunction
Microglia
Neuron
Online Access:http://link.springer.com/article/10.1186/s12974-018-1282-6

Internet

http://link.springer.com/article/10.1186/s12974-018-1282-6

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