Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity

Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity

Abstract Background Triptolide, an active ingredient of Chinese medicine plant Tripterygium wilfordii Hook.f., has been shown to exert anti-tumor, immunosuppressive, anti-inflammatory, and anti-fertility pharmacological effects. However, triptolide also causes severe side effects, which are manifest...

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Bibliographic Details
Main Authors: Yuan Wei, Dujun Wang, Meng Chen, Zhen Ouyang, Shuo Wang, Jun Gu
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Chinese Medicine
Subjects:
Triptolide
Xh-CL mouse model
Extrahepatic toxicity
Cytochrome P450
Pharmacokinetic
Online Access:http://link.springer.com/article/10.1186/s13020-018-0179-8

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http://link.springer.com/article/10.1186/s13020-018-0179-8

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