Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies

Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies

Neuromyelitis Optica Spectrum Disorders (NMOSD) are associated with autoantibodies (ABs) targeting the astrocytic aquaporin-4 water channels (AQP4-ABs). These ABs have a direct pathogenic role by initiating a variety of immunological and inflammatory processes in the course of disease. In a recently...

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Bibliographic Details
Main Authors: Benedikt Grünewald, Jeffrey L. Bennett, Klaus V. Toyka, Claudia Sommer, Christian Geis
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:International Journal of Molecular Sciences
Subjects:
NMOSD
aquaporin 4
autoantibody
IVIg
intrathecal application
Online Access:http://www.mdpi.com/1422-0067/17/9/1407

Internet

http://www.mdpi.com/1422-0067/17/9/1407

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