TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-α blockade

TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-α blockade

In Chagas disease, understanding how the immune response controls parasite growth but also leads to heart damage may provide insight into the design of new therapeutic strategies. Tumor necrosis factor-alpha (TNF-α) is important for resistance to acute Trypanosoma cruzi infection; however, in patien...

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Bibliographic Details
Main Authors: Karina Kroll-Palhares, Jaline Coutinho Silvério, Andrea Alice da Silva, Vladimir Michailowsky, Ana Paula Marino, Neide Maria Silva, Cristiano Marcelo Espinola Carvalho, Luzia Maria de Oliveira Pinto, Ricardo Tostes Gazzinelli, Joseli Lannes-Vieira
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2008-06-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
heart disease
inflammation
Trypanosoma cruzi
CCR5
TNFR1
TNF-α
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000400011&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000400011&lng=en&tlng=en

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