Impact of Arginine to Cysteine Mutations in Collagen II on Protein Secretion and Cell Survival

Impact of Arginine to Cysteine Mutations in Collagen II on Protein Secretion and Cell Survival

Inherited point mutations in collagen II in humans affecting mainly cartilage are broadly classified as chondrodysplasias. Most mutations occur in the glycine (Gly) of the Gly-X-Y repeats leading to destabilization of the triple helix. Arginine to cysteine substitutions that occur at either the X or...

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Bibliographic Details
Main Authors: Salin A. Chakkalakal, Juliane Heilig, Ulrich Baumann, Mats Paulsson, Frank Zaucke
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
collagen II
chondrodysplasia
mutation
unfolded protein response
triple helix
Online Access:http://www.mdpi.com/1422-0067/19/2/541

Internet

http://www.mdpi.com/1422-0067/19/2/541

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