Biological and Chemical Removal of Primary Cilia Affects Mechanical Activation of Chondrogenesis Markers in Chondroprogenitors and Hypertrophic Chondrocytes

Biological and Chemical Removal of Primary Cilia Affects Mechanical Activation of Chondrogenesis Markers in Chondroprogenitors and Hypertrophic Chondrocytes

Chondroprogenitors and hypertrophic chondrocytes, which are the first and last stages of the chondrocyte differentiation process, respectively, are sensitive to mechanical signals. We hypothesize that the mechanical sensitivity of these cells depends on the cell surface primary cilia. To test this h...

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Bibliographic Details
Main Authors: Matthew E. Deren, Xu Yang, Yingjie Guan, Qian Chen
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:International Journal of Molecular Sciences
Subjects:
primary cilia
mechanotransduction
chondrocytes
Online Access:http://www.mdpi.com/1422-0067/17/2/188

Internet

http://www.mdpi.com/1422-0067/17/2/188

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