Identifying the Integrated Neural Networks Involved in Capsaicin-Induced Pain Using fMRI in Awake TRPV1 Knockout and Wild-Type Rats

Identifying the Integrated Neural Networks Involved in Capsaicin-Induced Pain Using fMRI in Awake TRPV1 Knockout and Wild-Type Rats

In the present study, we used functional MRI in awake rats to investigate the pain response that accompanies intradermal injection of capsaicin into the hindpaw. To this end, we used BOLD imaging together with a 3D segmented, annotated rat atlas and computational analysis to identify the integrated...

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Bibliographic Details
Main Authors: Jason Richard Yee, William eKenkel, John eCaccaviello, Kevin eGamber, Phil eSimmons, Mark eNedelman, Praveen eKulkarni, Craig F Ferris
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Systems Neuroscience
Subjects:
Capsaicin
Habenula
TRPV1
fMRI methods
fMRI BOLD
Pain Networks
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00015/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00015/full

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