Hematopoietic Stem Cell Transplantation and Vasculopathy Associated With STAT3-Dominant-Negative Hyper-IgE Syndrome

Hematopoietic Stem Cell Transplantation and Vasculopathy Associated With STAT3-Dominant-Negative Hyper-IgE Syndrome

Dominant negative mutations in the transcription-factor STAT3 underlie the rare primary immunodeficiency Job's syndrome. Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) has shown promise in correction of the underlying immunological defect, with one report suggesting HSCT can prevent...

Full description

Bibliographic Details
Main Authors: Mark J. Ponsford, James Clark, Joel Mock, Mario Abinun, Emily Carne, Tariq El-Shanawany, Paul E. Williams, Anirban Choudhury, Alexandra F. Freeman, Andrew R. Gennery, Stephen Jolles
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pediatrics
Subjects:
Job's syndrome
STAT3 transcription factor
ST elevation myocardial infarction
coronary vessels
thrombosis
cardiovascular diseases
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.00575/full

Internet

https://www.frontiersin.org/article/10.3389/fped.2020.00575/full

Similar Items