Epileptiform activity during inert gas euthanasia of mice.

Carbon dioxide (CO2) is one of the most commonly used euthanasia agents for mice, yet it is highly aversive and nociceptive. Inert gases are a possible alternative, however there are qualitative reports of seizures resulting from exposure. Here we evaluate epileptiform activity caused by inert gases...

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Bibliographic Details
Main Authors: Thomas C Gent, Carlotta Detotto, Alexei L Vyssotski, Regula Bettschart-Wolfensberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5908136?pdf=render