Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice

Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice

Abstract Traumatic brain injury (TBI) is a significant cause of morbidity and mortality in the USA and other developed countries worldwide. Following the initial mechanical insult, the brain’s primary innate immune effector, microglia, initiate inflammatory signaling cascades and pathophysiological...

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Bibliographic Details
Main Authors: Josh M. Morganti, Danielle S. Goulding, Linda J. Van Eldik
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Neuroinflammation
Subjects:
TBI
p38α
Kinase
Microglia
Monocytes
Cytokines
Online Access:http://link.springer.com/article/10.1186/s12974-019-1493-5

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http://link.springer.com/article/10.1186/s12974-019-1493-5

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