APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains

APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains

Abstract Cerebrovascular dysfunction is a hallmark feature of Alzheimer's disease (AD). One of the greatest risk factors for AD is the apolipoprotein E4 (E4) allele. The APOE4 genotype has been shown to negatively impact vascular amyloid clearance, however, its direct influence on the molecular...

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Bibliographic Details
Main Authors: Joseph O. Ojo, Jon M. Reed, Gogce Crynen, Prashanthi Vallabhaneni, James Evans, Benjamin Shackleton, Maximillian Eisenbaum, Charis Ringland, Anastasia Edsell, Michael Mullan, Fiona Crawford, Corbin Bachmeier
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Brain
Subjects:
Cerebrovasculature
APOE
Aging
Alzheimer’s disease
Mural cells
Endothelial cells
Online Access:https://doi.org/10.1186/s13041-021-00803-9

Internet

https://doi.org/10.1186/s13041-021-00803-9

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