Nonlinear ridge regression improves cell-type-specific differential expression analysis
Abstract Background Epigenome-wide association studies (EWAS) and differential gene expression analyses are generally performed on tissue samples, which consist of multiple cell types. Cell-type-specific effects of a trait, such as disease, on the omics expression are of interest but difficult or co...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Bioinformatics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12859-021-03982-3 |