Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity

Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity

Abstract Background Epimedii Folium (EF) is commonly used for treating bone fractures and joint diseases, but the potential hepatotoxicity of EF limits its clinical application. Our previous study confirms that EF could lead to idiosyncratic drug-induced liver injury (IDILI) and hepatocyte apoptosis...

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Bibliographic Details
Main Authors: Yuan Gao, Guang Xu, Li Ma, Wei Shi, Zhilei Wang, Xiaoyan Zhan, Nan Qin, Tingting He, Yuming Guo, Ming Niu, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell Communication and Signaling
Subjects:
Epimedii folium
Icariside I
Idiosyncratic drug-induced liver injury
NLRP3 inflammasome
Online Access:https://doi.org/10.1186/s12964-020-00647-1

Internet

https://doi.org/10.1186/s12964-020-00647-1

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