Nicotinamide phosphoribosyltransferase: Biology, role in cancer, and novel drug target

Nicotinamide phosphoribosyltransferase: Biology, role in cancer, and novel drug target

The nicotinamide adenine dinucleotide (NAD+) pool is an important electron exchanger in tumor biology. The salvage pathway plays an important role in the regulation of the levels of cellular NAD+ biosynthesis and the nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme of this...

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Bibliographic Details
Main Authors: Antonio Lucena-Cacace, Amancio Carnero
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Cancer Translational Medicine
Subjects:
Cancer stem cells
nicotinamide adenine dinucleotide
nicotinamide phosphoribosyltransferase
salvage pathway
therapy resistance
Online Access:http://www.cancertm.com/article.asp?issn=2395-3977;year=2018;volume=4;issue=4;spage=109;epage=116;aulast=Lucena-Cacace

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http://www.cancertm.com/article.asp?issn=2395-3977;year=2018;volume=4;issue=4;spage=109;epage=116;aulast=Lucena-Cacace

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