Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.

Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.

<h4>Background</h4>HIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibitin...

Full description

Bibliographic Details
Main Authors: Weibin Zha, Guangji Wang, Weiren Xu, Xuyuan Liu, Yun Wang, Beth S Zha, Jian Shi, Qijin Zhao, Phillip M Gerk, Elaine Studer, Phillip B Hylemon, William M Pandak, Huiping Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23372711/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23372711/?tool=EBI

Similar Items