Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine

Despite the success of current vaccination against poliomyelitis, safe, cheap and effective vaccines remain sought for continuing eradication effort. Here the authors use plants to express stabilized virus-like particles of type 3 poliovirus that can induce a protective immune response in mice trans...

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Main Authors:	Johanna Marsian, Helen Fox, Mohammad W. Bahar, Abhay Kotecha, Elizabeth E. Fry, David I. Stuart, Andrew J. Macadam, David J. Rowlands, George P. Lomonossoff
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00090-w

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spelling	doaj-48bce09b6ee24f948fdf9a32e9d5ba0a2021-01-31T12:32:28ZengNature Publishing GroupNature Communications2041-17232017-08-01811910.1038/s41467-017-00090-wPlant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccineJohanna Marsian0Helen Fox1Mohammad W. Bahar2Abhay Kotecha3Elizabeth E. Fry4David I. Stuart5Andrew J. Macadam6David J. Rowlands7George P. Lomonossoff8John Innes Centre, Norwich Research ParkThe National Institute for Biological Standards and ControlDivision of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic MedicineDivision of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic MedicineDivision of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic MedicineDivision of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic MedicineThe National Institute for Biological Standards and ControlSchool of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of LeedsJohn Innes Centre, Norwich Research ParkDespite the success of current vaccination against poliomyelitis, safe, cheap and effective vaccines remain sought for continuing eradication effort. Here the authors use plants to express stabilized virus-like particles of type 3 poliovirus that can induce a protective immune response in mice transgenic for the human poliovirus receptor.https://doi.org/10.1038/s41467-017-00090-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Johanna Marsian Helen Fox Mohammad W. Bahar Abhay Kotecha Elizabeth E. Fry David I. Stuart Andrew J. Macadam David J. Rowlands George P. Lomonossoff
spellingShingle	Johanna Marsian Helen Fox Mohammad W. Bahar Abhay Kotecha Elizabeth E. Fry David I. Stuart Andrew J. Macadam David J. Rowlands George P. Lomonossoff Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine Nature Communications
author_facet	Johanna Marsian Helen Fox Mohammad W. Bahar Abhay Kotecha Elizabeth E. Fry David I. Stuart Andrew J. Macadam David J. Rowlands George P. Lomonossoff
author_sort	Johanna Marsian
title	Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine
title_short	Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine
title_full	Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine
title_fullStr	Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine
title_full_unstemmed	Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine
title_sort	plant-made polio type 3 stabilized vlps—a candidate synthetic polio vaccine
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-08-01
description	Despite the success of current vaccination against poliomyelitis, safe, cheap and effective vaccines remain sought for continuing eradication effort. Here the authors use plants to express stabilized virus-like particles of type 3 poliovirus that can induce a protective immune response in mice transgenic for the human poliovirus receptor.
url	https://doi.org/10.1038/s41467-017-00090-w
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Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine

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