Disorder of Coagulation-Fibrinolysis System: An Emerging Toxicity of Anti-PD-1/PD-L1 Monoclonal Antibodies

Disorder of Coagulation-Fibrinolysis System: An Emerging Toxicity of Anti-PD-1/PD-L1 Monoclonal Antibodies

A disruption of immune checkpoints leads to imbalances in immune homeostasis, resulting in immune-related adverse events. Recent case studies have suggested the association between immune checkpoint inhibitors (ICIs) and the disorders of the coagulation-fibrinolysis system, implying that systemic im...

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Bibliographic Details
Main Authors: Ryo Sato, Kosuke Imamura, Shinya Sakata, Tokunori Ikeda, Yuko Horio, Shinji Iyama, Kimitaka Akaike, Shohei Hamada, Takayuki Jodai, Kei Nakashima, Shiho Ishizuka, Nahoko Sato, Koichi Saruwatari, Sho Saeki, Yusuke Tomita, Takuro Sakagami
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Journal of Clinical Medicine
Subjects:
immune-related adverse events (irAEs)
immune checkpoint inhibitor (ICI)
non-small-cell lung cancer (NSCLC)
programmed cell death 1 (PD-1)
programmed cell death ligand 1 (PD-L1)
T cell
tissue factor (TF)
Trousseau’s syndrome
monocyte
macrophage
Online Access:https://www.mdpi.com/2077-0383/8/6/762

Internet

https://www.mdpi.com/2077-0383/8/6/762

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