Head-to-head comparison of aggressive conventional therapy and three biological treatments and comparison of two de-escalation strategies in patients who respond to treatment: study protocol for a multicenter, randomized, open-label, blinded-assessor, phase 4 study

Head-to-head comparison of aggressive conventional therapy and three biological treatments and comparison of two de-escalation strategies in patients who respond to treatment: study protocol for a multicenter, randomized, open-label, blinded-assessor, phase 4 study

Abstract Background New targeted therapies and improved treatment strategies have dramatically improved the outcomes of patients with rheumatoid arthritis (RA). However, it is unknown whether different early aggressive interventions can induce stable remission or a low-active disease state that can...

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Bibliographic Details
Main Authors: Daniel Glinatsi, Marte S. Heiberg, Anna Rudin, Dan Nordström, Espen A. Haavardsholm, Bjorn Gudbjornsson, Mikkel Østergaard, Till Uhlig, Gerdur Grondal, Kim Hørslev-Petersen, Ronald van Vollenhoven, Merete L. Hetland
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Trials
Subjects:
Rheumatoid arthritis
Early treatment
Biological treatment
Aggressive conventional treatment
Sustained remission
De-escalation strategy
Online Access:http://link.springer.com/article/10.1186/s13063-017-1891-x

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http://link.springer.com/article/10.1186/s13063-017-1891-x

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