TNFAIP8 promotes AML chemoresistance by activating ERK signaling pathway through interaction with Rac1

TNFAIP8 promotes AML chemoresistance by activating ERK signaling pathway through interaction with Rac1

Abstract Background Chemoresistance is emerging as a major barrier to successful treatment in acute myeloid leukemia (AML), and evasion of apoptosis is among the fundamental underlying mechanisms. Therefore, unraveling molecular networks that drive this process constitutes an urgent unmet need. Here...

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Bibliographic Details
Main Authors: Yihua Pang, Yanan Zhao, Yan Wang, Xinlu Wang, Ruiqing Wang, Na Liu, Peng Li, Min Ji, Jingjing Ye, Tao Sun, Jingxin Li, Daoxin Ma, Fei Lu, Chunyan Ji
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TNFAIP8
Apoptosis
Chemoresistance
ERK
Rac1
AML
Online Access:http://link.springer.com/article/10.1186/s13046-020-01658-z

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http://link.springer.com/article/10.1186/s13046-020-01658-z

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