GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.

GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.

BACKGROUND: Functional GABA(B) receptor is believed to require hetero-dimerization between GABA(B1) (GB1) and GABA(B2) (GB2) subunits. The GB1 extracellular domain is required for ligand binding, and the GB2 trans-membrane domain is responsible for coupling to G proteins. Atypical GABA(B) receptor r...

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Bibliographic Details
Main Authors: Guillaume A Baloucoune, Lei Chun, Wenhua Zhang, Chanjuan Xu, Siluo Huang, Qian Sun, Yunyun Wang, Haijun Tu, Jianfeng Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3386256?pdf=render

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http://europepmc.org/articles/PMC3386256?pdf=render

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