GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
BACKGROUND: Functional GABA(B) receptor is believed to require hetero-dimerization between GABA(B1) (GB1) and GABA(B2) (GB2) subunits. The GB1 extracellular domain is required for ligand binding, and the GB2 trans-membrane domain is responsible for coupling to G proteins. Atypical GABA(B) receptor r...
Main Authors: | Guillaume A Baloucoune, Lei Chun, Wenhua Zhang, Chanjuan Xu, Siluo Huang, Qian Sun, Yunyun Wang, Haijun Tu, Jianfeng Liu |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3386256?pdf=render |
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