Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM

Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor survival. Age is a major risk factor, and both alveolar epithelial cells and lung fibroblasts in this disease exhibit features of cellular senescence, a hallmark of ageing. Accumulation of fibrotic extracellular matrix (ECM)...

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Bibliographic Details
Main Authors: Kaj E. C. Blokland, Habibie Habibie, Theo Borghuis, Greta J. Teitsma, Michael Schuliga, Barbro N. Melgert, Darryl A. Knight, Corry-Anke Brandsma, Simon D. Pouwels, Janette K. Burgess
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
extracellular matrix
senescence
idiopathic pulmonary fibrosis
proinflammatory
profibrotic
Online Access:https://www.mdpi.com/2073-4409/10/7/1628

Internet

https://www.mdpi.com/2073-4409/10/7/1628

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