Exosomes derived from human CD34+ stem cells transfected with miR-26a prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis and osteogenesis

Exosomes derived from human CD34+ stem cells transfected with miR-26a prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis and osteogenesis

Abstract Background Damaged endothelial cells and downregulated osteogenic ability are two key pathogenic mechanisms of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Recent studies suggested that transplantation of CD34+ stem cell-derived exosomes (CD34+-Exos) can treat ische...

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Bibliographic Details
Main Authors: Rongtai Zuo, Lingchi Kong, Mengwei Wang, Wenbo Wang, Jia Xu, Yimin Chai, Junjie Guan, Qinglin Kang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Stem Cell Research & Therapy
Subjects:
Osteonecrosis of the femoral head
Glucocorticoids
CD34+ stem cells
Exosomes
miR-26a
Angiogenesis
Online Access:http://link.springer.com/article/10.1186/s13287-019-1426-3

Internet

http://link.springer.com/article/10.1186/s13287-019-1426-3

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