Microspheres prepared with biodegradable PHBV and PLA polymers as prolonged-release system for ibuprofen: in vitro drug release and in vivo evaluation

Microspheres prepared with biodegradable PHBV and PLA polymers as prolonged-release system for ibuprofen: in vitro drug release and in vivo evaluation

In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and poly(l-lactide) (PLA) microspheres containing ibuprofen were prepared with the aim of prolonging the drug release. The oil-in-water (O/W) emulsion solvent evaporation technique was used, varying the polymer ratio. All formulations pr...

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Bibliographic Details
Main Authors: Giovana Carolina Bazzo, Aline Teixeira de Macedo, Janine Paula Crenca, Virgínia Emiliana Silva, Eduardo Manoel Pereira, Melissa Zétola, Bianca Ramos Pezzini
Format: Article
Language:English
Published: Universidade de São Paulo 2012-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Microesferas
Poli(hidroxibutirato-co-hidroxivalerato)
Poli(ácido láctico)
Ibuprofeno
Fármacos
Microspheres
Poly(hydroxybutyrate-co-hydroxyvalerate)
Poly(l-lactide)
Ibuprofen
Drugs
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400021

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400021

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