Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis

Monitoring changes in immune phenotype during the progression of multiple sclerosis can provide insight into disease progression and inform treatment. Here the authors develop engineered biomaterial-based immunological niches for easy access to innate immune cells in a mouse model of multiple sclero...

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Main Authors:	Aaron H. Morris, Kevin R. Hughes, Robert S. Oakes, Michelle M. Cai, Stephen D. Miller, David N. Irani, Lonnie D. Shea
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17629-z

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spelling	doaj-48cb7a477ac048fcac336e50307857782021-08-08T11:38:14ZengNature Publishing GroupNature Communications2041-17232020-08-011111910.1038/s41467-020-17629-zEngineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosisAaron H. Morris0Kevin R. Hughes1Robert S. Oakes2Michelle M. Cai3Stephen D. Miller4David N. Irani5Lonnie D. Shea6Department of Biomedical Engineering, University of MichiganDepartment of Biomedical Engineering, University of MichiganDepartment of Biomedical Engineering, University of MichiganDepartment of Biomedical Engineering, University of MichiganDepartment of Microbiology–Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of MedicineDepartment of Neurology, University of Michigan Medical SchoolDepartment of Biomedical Engineering, University of MichiganMonitoring changes in immune phenotype during the progression of multiple sclerosis can provide insight into disease progression and inform treatment. Here the authors develop engineered biomaterial-based immunological niches for easy access to innate immune cells in a mouse model of multiple sclerosis.https://doi.org/10.1038/s41467-020-17629-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Aaron H. Morris Kevin R. Hughes Robert S. Oakes Michelle M. Cai Stephen D. Miller David N. Irani Lonnie D. Shea
spellingShingle	Aaron H. Morris Kevin R. Hughes Robert S. Oakes Michelle M. Cai Stephen D. Miller David N. Irani Lonnie D. Shea Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis Nature Communications
author_facet	Aaron H. Morris Kevin R. Hughes Robert S. Oakes Michelle M. Cai Stephen D. Miller David N. Irani Lonnie D. Shea
author_sort	Aaron H. Morris
title	Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis
title_short	Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis
title_full	Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis
title_fullStr	Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis
title_full_unstemmed	Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis
title_sort	engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-08-01
description	Monitoring changes in immune phenotype during the progression of multiple sclerosis can provide insight into disease progression and inform treatment. Here the authors develop engineered biomaterial-based immunological niches for easy access to innate immune cells in a mouse model of multiple sclerosis.
url	https://doi.org/10.1038/s41467-020-17629-z
work_keys_str_mv	AT aaronhmorris engineeredimmunologicalnichestomonitordiseaseactivityandtreatmentefficacyinrelapsingmultiplesclerosis AT kevinrhughes engineeredimmunologicalnichestomonitordiseaseactivityandtreatmentefficacyinrelapsingmultiplesclerosis AT robertsoakes engineeredimmunologicalnichestomonitordiseaseactivityandtreatmentefficacyinrelapsingmultiplesclerosis AT michellemcai engineeredimmunologicalnichestomonitordiseaseactivityandtreatmentefficacyinrelapsingmultiplesclerosis AT stephendmiller engineeredimmunologicalnichestomonitordiseaseactivityandtreatmentefficacyinrelapsingmultiplesclerosis AT davidnirani engineeredimmunologicalnichestomonitordiseaseactivityandtreatmentefficacyinrelapsingmultiplesclerosis AT lonniedshea engineeredimmunologicalnichestomonitordiseaseactivityandtreatmentefficacyinrelapsingmultiplesclerosis
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Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis

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