The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain

Neuropathic pain results from neuroplasticity in nociceptive neuronal networks. Here we demonstrate that control of alternative pre-mRNA splicing, through the splice factor serine-arginine splice factor 1 (SRSF1), is integral to the processing of nociceptive information in the spinal cord.Neuropathi...

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Bibliographic Details
Main Authors: Richard P. Hulse, Robert A.R. Drake, David O. Bates, Lucy F. Donaldson
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302261