Excessive Reactive Iron Impairs Hematopoiesis by Affecting Both Immature Hematopoietic Cells and Stromal Cells

Excessive Reactive Iron Impairs Hematopoiesis by Affecting Both Immature Hematopoietic Cells and Stromal Cells

Iron overload is the accumulation of excess iron in the body that may occur as a result of various genetic disorders or as a consequence of repeated blood transfusions. The surplus iron is then stored in the liver, pancreas, heart and other organs, which may lead to chronic liver disease or cirrhosi...

Full description

Bibliographic Details
Main Authors: Hirokazu Tanaka, J. Luis Espinoza, Ryosuke Fujiwara, Shinya Rai, Yasuyoshi Morita, Takashi Ashida, Yuzuru Kanakura, Itaru Matsumura
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
hematopoiesis
iron overload
hematopoietic stem cells
stromal cells
oxidative stress
Online Access:http://www.mdpi.com/2073-4409/8/3/226

Internet

http://www.mdpi.com/2073-4409/8/3/226

Similar Items