The rapid in vivo evolution of Pseudomonas aeruginosa in ventilator-associated pneumonia patients leads to attenuated virulence

The rapid in vivo evolution of Pseudomonas aeruginosa in ventilator-associated pneumonia patients leads to attenuated virulence

Pseudomonas aeruginosa is an opportunistic pathogen that causes severe airway infections in humans. These infections are usually difficult to treat and associated with high mortality rates. While colonizing the human airways, P. aeruginosa could accumulate genetic mutations that often lead to its be...

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Bibliographic Details
Main Authors: Ke Wang, Yi-qiang Chen, May M. Salido, Gurjeet S. Kohli, Jin-liang Kong, Hong-jie Liang, Zi-ting Yao, Yan-tong Xie, Hua-yu Wu, Shuang-qi Cai, Daniela I. Drautz-Moses, Aaron E. Darling, Stephan C. Schuster, Liang Yang, Yichen Ding
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Open Biology
Subjects:
pseudomonas aeruginosa
ventilator-associated pneumonia
in vivo evolution
genomics
adaptation
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170029

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170029

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