Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis

Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis

Acarose is an anti-diabetic drug and exhibits anti-arthritic effects. We hypothesized that acarbose influences the gut microbiota to affect the course of arthritis and tested this hypothesis in a collagen-induced arthritis (CIA) murine model. Acarbose in drinking water was administered via gastric g...

Full description

Bibliographic Details
Main Authors: Lingshu Zhang, Pingfang Song, Xiaowei Zhang, Christina Metea, Matthew Schleisman, Lisa Karstens, Eric Leung, Jun Zhang, Qiang Xu, Yi Liu, Mark Asquith, Cong-Qiu Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
acarbose
arthritis (including rheumatoid arthritis)
microbiome
Th17
Treg cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01684/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01684/full

Similar Items