Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization

Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization

Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on t...

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Bibliographic Details
Main Authors: Éva Kárpáti, Alexandra Papp, Andrea E. Schneider, Dávid Hajnal, Marcell Cserhalmi, Ádám I. Csincsi, Barbara Uzonyi, Mihály Józsi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
complement
factor H protein family
pentraxin
necrotic cell
DNA
opsonization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01297/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01297/full

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